This chapter examines the changing nature of the professions and how they cope with the impact of technology on their fields. An ethical framework for decision making is developed. Professional and ethical responsibilities based on community values and the law are also discussed. Social issues including harassment and discrimination are thoroughly covered. Discussed in depth are the four pillars of professionalism that include commitment, integrity, responsibility, and accountability. We focus our discussion on professional dilemmas and guilt associated with decision making showing that these dilemmas, which are quite common in the everyday activities of a professional, are caused by questioning the values attached to one’s premises as inputs to the decision being made and that one’s input values may be clouded by conflicting codes of conduct, advances in technology, and/or incomplete or misleading information. We end the chapter with an in-depth discussion of professionalism and ethical responsibilities focusing on whistle-blowing, harassment, and discrimination.